Elastosis perforans serpiginosa (EPS) is a rare disorder classified as a primary perforating dermatosis. That group of diseases also includes. Four types of elastosis perforans serpiginosa (EPS) have been described in literature: 1) idiopathic EPS, 2) reactive perforating elastosis. Elastosis perforans serpiginosa (EPS) is a rare dermatologic condition where connective and elastic tissues are viewed as foreign objects and subsequently.

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J Am Acad Dermatol ; Based on these findings, a diagnosis of elastosis perforans serpisinosa was made. By using this site, serpiglnosa agree to the Terms of Use and Privacy Policy.

Usually it spontaneously resolves without complications after a few years. Report of a case and review of the literature.

Elastosis perforans serpiginosa – Wikipedia

Journal List Ann Dermatol v. EPS presents as a cluster of small reddish bumps mm in diameter, often grouped in linearcircular or serpiginous snake-like patterns. Sign in to save your search Sign in to your personal account. How to cite this URL: D-penicillamine percorans EPS has a perforxns histopathologic feature – serrated appearance of elastic fibers due to perpendicular budding from their surface giving a “lumpy-bumpy” look. DermNet NZ does not provide an online consultation service. Privacy Policy Terms of Use.

Degenerative diseases and perforating disorders. This condition classically presents as small papules arranged in serpiginous or annular patterns on the neck, face, arms, or other flexural areas.

Patient 2 then discontinued tazarotene therapy, and her disease flared. Conflict of interest The authors declare no conflict of interest. Due to its rarity, EPS often remains unrecognized, but the diagnosis should always be taken into account in children, in whom annular lesions on the face and neck can be visualized. Notably, two of the five reported Korean patients with EPS had comorbid pseudoxanthoma elasticum. Physical examination revealed multiple 2- to 7-mm crusted, erythematous, ulcerated papules and plaques with an arcuate configuration.


In addition, discontinuing penicillamine therapy does not guarantee preventing further development of EPS lesions in patients undergoing penicillamine therapy 15 How to cite this article: In addition, the patient was suffering from hypothyroidism, tetralogy of Fallot and bilateral congenital dislocation of the hip joints.

Indian J Dermatol Venereol Leprol ; Elastosis perforans serpiginosa is a unique perforating disorder characterized by transepidermal elimination of elastic fibers and distinctive clinical lesionswhich are serpiginous in distribution and can be associated with specific diseases.

Create a free personal account to download free article PDFs, sign up for alerts, and more. Our website uses cookies to enhance your experience. The D-penicillamine therapy had been discontinued 2 months before her presentation to our clinic.

Disorders of transepidermal elimination. Increased elastic tissue and solar elastotic syndromes. Elastosis perforans serpiginosa with simultaneous onset in two sisters.

We report a case of D-penicillamine induced widespread alteration in skin elastic tissue with distinct histopathologic features. After 2 months of tazarotene therapy, the condition of patient 1 was greatly improved Figure 3 and that of patient 2 was moderately improved.

Elastosis perforans serpiginosa: a review of the literature and our own experience

Such a case of EPS associated with penicillamine therapy was reported in the Korean prrforans 5. After obtaining the result of the histopathological examination, the nature of the disease, possibilities as well as the effectiveness and purpose of the treatment were explained to the parents. There have not been published any reports about EPS and Koebner phenomenon so far.


Numerous treatment modalities have been described, including dry ice 8cellophane tape stripping 813electrodessication and curettage 14cryotherapy 13 – elatsosisintralesional and topical corticosteroid therapy serpiginoda16topical calcipotriol 14topical tretinoin 141517oral isotretinoin 1415topical tazarotene 15topical imiquimod 18topical glycolic or salicylic acid therapy 1417narrow pwrforans ultraviolet B radiation 14pulsed dye laser, Er: The disease prevalence has not been clearly specified so far but this is not a condition commonly found in routine clinical practice.

Support Center Support Center. Etiology and pathogenesis of EPS has not yet been fully understood. Elastosis perforans serpiginosa associated with pseudo-pseudoxanthoma elasticum during treatment of Wilson’s perforand with penicillamine. A list of possible co-morbidities of EPS is shown in Table 1 [ 3 — 6 ]. Localized scleroderma Localized morphea Morphea—lichen sclerosus et atrophicus overlap Generalized morphea Atrophoderma of Pasini and Pierini Pansclerotic morphea Morphea profunda Linear scleroderma.

National Center for Biotechnology InformationU. Keratoderma climactericum Paraneoplastic keratoderma Acrokeratosis paraneoplastica of Bazex Aquagenic keratoderma Drug-induced keratoderma psoriasis Keratoderma blennorrhagicum keratosis: